Impacto de la regulación epigenética durante las infecciones bacterianas

Hortensia Patricia Cuéllar Mata; Marco Antonio Barajas Mendiola

Authors

Hortensia Patricia Cuéllar Mata Departamento de Biología, Universidad de Guanajuato. Guanajuato, Guanajuato, México. https://orcid.org/0000-0003-2898-9845
Marco Antonio Barajas Mendiola Departamento de Biología, Universidad de Guanajuato. Guanajuato, Guanajuato, México. https://orcid.org/0009-0008-8159-8185

Keywords:

immune response, bacterial infections, epigenetics

Abstract

Epigenetics studies the mechanisms regulating the gene expression without altering the DNA sequence, which can be heritable, reversible, and influenced by the environment. Among these, epigenetic mechanisms such as chemical modifications in histones and the expression of micro RNAs (miRNAs) are important regulators of the immune response, since they can regulate and control the magnitude of the response during an infection. However, bacteria have established strategies that allow them to manipulate these epigenetic mechanisms, allowing them to evade the immune response, survive, and persist chronically in the host. This work focuses on the strategies used by bacteria to modulate the epigenetic mechanisms that allow them to evade the immune response and persist in the host. A better understanding of epigenetics in bacterial infections can establish new bases for the development of therapies that minimize the use of antibiotics.

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Author Biographies

Hortensia Patricia Cuéllar Mata, Departamento de Biología, Universidad de Guanajuato. Guanajuato, Guanajuato, México.

Profesora Investigadora C y Directora del Departamento de Biología, División de Ciencias Naturales y Exacatas, de la Universidad de Guanajuato. Desarrolla lineas de investigación en Inmunobiolgia, particualrmete evaluando el efecto de moleculas inmunomoduladores (ej. péptidos antimicrobianos , exosomas) sobre la respuesta inmune innata en la interacción hospedero.patógeno en modelos in vitro e in vivo de tricomionasis. Actualemnte es mienmbre del sisntema nacional de investigadors e investigadoras nivel 1, contando con el perfil PRODEP.

Marco Antonio Barajas Mendiola, Departamento de Biología, Universidad de Guanajuato. Guanajuato, Guanajuato, México.

Profesor Asociado

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