“Antimicrobial uses of usnic acid: A natural alternative”
DOI:
https://doi.org/10.35830/mcya.vi26.598Keywords:
Usnic acid, Antimicrobial agents, Bacterial resistanceAbstract
Usnic acid, a natural compound produced by lichens, has attracted increasing interest in the scientific community due to its antimicrobial, antioxidant and antiviral properties. This substance works by inhibiting the growth of bacteria, including antibiotic-resistant strains, and has shown potential in the treatment of viral infections such as those caused by the SARS-CoV-2 virus. Furthermore, its antioxidant capacity allows it to protect cellular DNA, which suggests applications in the prevention of chronic diseases. However, usnic acid is not without limitations: its low water solubility and possible hepatotoxic effects represent significant challenges. This article explores the medical uses of usnic acid, its benefits, challenges and future prospects, highlighting the need for additional research to establish its safety and efficacy in humans. Despite the obstacles, usnic acid is emerging as a promising natural alternative for the development of new drugs used in the fight against resistant infections and viral diseases.
Downloads
References
Ávila-Zamora, S., Pinzon-Pérez, Y. y Acero-Godoy, J. (2023). Artículo de revisión. Ácido úsnico: alternativa potencial contra la resistencia bacteriana actual. Tecnología en Marcha. 36(3), 145-157. https://doi.org/10.18845/tm.v36i3.6183
Chen, S., Ren, Z., y Guo, L. (2025). Hepatotoxicity of usnic acid and underlying mechanisms. Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 43(1), 1-22. https://doi.org/10.1080/26896583.2024.2366737
Filimonov, S., Yarovaya, I., Zaykovskaya, V., Rudometova, B., Shcherbakov, N., Chirkova, Y., Baev, S., Borisevich, S., Luzina, A., Pyankov, V., Maksyutov, R. y Salakhutdinov, F. (2022). (+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses. Viruses, 14(10), 2154. https://doi.org/10.3390/v14102154
Gangwar, B., Kumar, S., Kumar, P., Pal, A., y Darokar, P. (2024). Mechanistic Insight into the Antimicrobial Mode of Action of Usnic Acid and Its Synergy with Norfloxacin against Methicillin Resistant Staphylococcus aureus. Preprints. https://doi.org/10.20944/preprints202407.2326.v1
Guo, L., Shi, Q., Fang, J. L., Mei, N., Ali, A. A., Lewis, S. M., Leakey, J. E., y Frankos, V. H. (2008). Review of usnic acid and Usnea barbata toxicity. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 26(4), 317-338. https://doi.org/10.1080/10590500802533392
Herbarium. (S.F.). Cladonia spp (Cladoniaceae). https://www.plantasyhongos.es/herbarium/htm/Cladonia_spp.htm
Herbert, B. (S.F.). Old Man´s Beard Lichen. Shutterstock. https://www.shutterstock.com/es/image-photo/old-mans-beard-lichen-close552575908
Herrera, S. y Bruguera, M. (2008). Hepatotoxicidad inducida por el uso de hierbas y medicamentos para perder peso. Progresos en Hepatología. 31(7). 447-453. https://www.elsevier.es/es-revista-gastroenterologia-hepatologia-14-pdf-S0210570508756498
Hitendra, Y., Nayaka, S. y Dwivedi, M. (2021). Analytics on Antimicrobial Activity of Lichen Extract. J Pure Appl Microbiol. 15(2), 701-708. https://doi.org/10.22207/JPAM.15.2.21
Khan, F., Yu, H., y Kim, M. (2020). Bactericidal Activity of Usnic Acid-Chitosan Nanoparticles against Persister Cells of Biofilm-Forming Pathogenic Bacteria. Marine Drugs, 18(5), 270. https://doi.org/10.3390/md18050270
Kiliç, S., Kocakaya, Z., Karatoprak, ., lgün, S., y Ceylan, A. (2023). Analyzing the Impact of Ramalina digitellata, R. fastigiata, R. fraxinea, and R. polymorpha’s Usnic Acid Concentration on Antioxidant, DNA-Protective, Antimicrobial, and Cytotoxic Properties. Chemistry & biodiversity, 20(1), e202200816. https://doi.org/10.1002/cbdv.202200816
Maltezou, C., Horefti, E., Papamichalopoulos, N., Tseroni, M., Ioannidis, A., Angelakis, E., y Chatzipanagiotou, S. (2022). Antimicrobial Effectiveness of an Usnic-Acid-Containing Self Decontaminating Coating on Underground Metro Surfaces in Athens. Microorganisms, 10(11), 2233. https://doi.org/10.3390/microorganisms10112233
Nagaraju, B., Fathimunnisa, K., Vijayaraghavan, R. y Sreekanth, B. (2022). Antibacterial Activity of (+) Usnic Acid against Multi Drug Resistant Acinetobacter baumannii from Clinical Isolates. Indian Journal of Forensic Medicine & Toxicology, 16(1), 11. https://doi.org/10.37506/ijfmt.v16i1.17407
Oh, E., Wang, W., Park, K. H., Park, C., Cho, Y., Lee, J., Kang, E., y Kang, H. (2022). (+)-Usnic acid and its salts, inhibitors of SARS-CoV-2, identified by using in silico methods and in vitro assay. Scientific reports, 12(1), 13118. https://doi.org/10.1038/s41598-022-17506-3
Pérez, M. (2021). La pandemia silenciosa: resistencia bacteriana a los antibióticos. CEU Ediciones. https://www.researchgate.net/publication/363113312
Ruddell, S., Mostert, D. y Sieber Stephan. (2024). Target identification of usnic acid in bacterial and human cells. RSC Chem. Biol. 5, 617-621. https://doi.org/10.1039/D4CB00040D
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Milenaria, Ciencia y arte

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
