Exploring Ferroptosis
DOI:
https://doi.org/10.35830/mcya.vi25.608Keywords:
IronAbstract
Ferroptosis is a newly discovered form of cell death triggered by dysregulation in the metabolism of iron, glutathione, and lipids, a process characterized by progressive oxidation of cell membranes, where iron acts as a catalyst for destructive reactions. Researchers have found significant links between ferroptosis and various conditions such as neurodegenerative diseases and cellular aging. However, its potential as a tumor suppressor in cancer has also been explored. In this article, we will explore this fascinating process that reveals the dual nature of iron: essential for life but potentially destructive.
Downloads
References
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., Morrison, B., III, & Stockwell, B. R. (2012). Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149(5), 1060–1072. https://doi.org/10.1016/j.cell.2012.03.042
Dixon, S. J., & Olzmann, J. A. (2024). The cell biology of ferroptosis. Nature Reviews. Molecular Cell Biology, 25(6), 424–442. https://doi.org10.1038/s41580-024-00703-5
Lane, D. J. R., Metselaar, B., Greenough, M., Bush, A. I., & Ayton, S. J. (2021). Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer’s disease. Essays in Biochemistry, 65(7), 925–940. https://doi.org/10.1042/ebc20210017
Peña-Montes, D. J., & Saavedra-Molina, A. (2024). El papel de la ferroptosis en la enfermedad renal diabética. TIP Revista Especializada en Ciencias Químico-Biológicas, 27, 1–14. https://doi.org/10.22201/fesz.23958723e.2024.684
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., Noel, K., Jiang, X., Linkermann, A., Murphy, M. E., Overholtzer, M., Oyagi, A., Pagnussat, G. C., Park, J., Ran, Q., … Zhang, D. D. (2017). Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell, 171(2), 273–285. https://doi.org/10.1016/j.cell.2017.09.021
Zhou, R.-P., Chen, Y., Wei, X., Yu, B., Xiong, Z.-G., Lu, C., & Hu, W. (2020). Novel insights into ferroptosis: Implications for age-related diseases. Theranostics, 10(26), 11976–11997. https://doi.org/10.7150/thno.50663
“10 Years on Ferroptosis Discovery: Potential in Disease Treatment”. Wms-site.com, https://wms-site.com/press-media/1109-10-years-on-ferroptosis-discovery-potential-in-disease-treatment. Consultado el 19 de enero de 2025.
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Milenaria, Ciencia y arte

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.